Relationship between C-reactive protein and periodontal disease: A new tale of an old molecule

Review Article

Author Details : Avneesh Tejnani*, Adil Gandevivala, Devang Bhanushali

Volume : 6, Issue : 1, Year : 2021

Article Page : 11-17

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Oral fluids are a substrate for a new generation of non-invasive diagnostic tools through the development of ultra- and high-sensitive detection systems and the fact that they contain many serum analytes that reflect normal function or disease status.Within the oral cavity C-reactive protein (CRP) has been detected in both gingival crevicular fluid (GCF) and saliva, and is considered to be an important biomarker for systemic disease.We review the biological properties of CRP, the association between CRP and periodontal disease, and the possibility that CRP may be a potent therapeutic target. A systematic search for data related to the association between CRP and periodontal disease was performed to recognize studies on animals and
human (PUBMED, MEDLINE, COCHRANE, and Google search).

Keywords: Acute phase reactants, Creactive protein, Cardiovascular disease, Periodontal disease.

How to cite : Tejnani A , Gandevivala A , Bhanushali D , Relationship between C-reactive protein and periodontal disease: A new tale of an old molecule. IP Int J Periodontol Implantol 2021;6(1):11-17

Copyright © 2021 by author(s) and IP Int J Periodontol Implantol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 17-03-2021

Accepted : 20-03-2021

Available online : 16-04-2021

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